Catalog
Neuroendocrine Receptor Signaling · Evidence Level III

Melanotan II

Melanocortin analogue

Melanotan II is a synthetic cyclic melanocortin analogue studied in pigmentation, melanocortin receptor pharmacology, appetite, autonomic responses, and sexual-function pathways.

For laboratory and research use only. Not for human or veterinary use.

Form

Lyophilized

Available strengths

10 mg

Research class

Neuroendocrine Receptor Signaling

Evidence grade

Level III

Limited or preliminary human evidence

01

Scientific overview

Melanotan II is a synthetic cyclic melanocortin analogue studied in pigmentation, melanocortin receptor pharmacology, appetite, autonomic responses, and sexual-function pathways.

02

Mechanism under investigation

Agonizes multiple melanocortin receptors, including MC1R and central melanocortin receptors, producing broad and nonselective signaling.

03

Research evidence summary

Limited human investigation with substantial safety concerns.

Level III, Limited human evidence

04

Key research limitations

The compound is not an approved tanning or wellness product. Commercial materials may have uncertain identity and purity.

05

Safety & toxicology context

Reported concerns include nausea, flushing, blood-pressure changes, priapism, pigment changes, sympathomimetic toxicity, and serious neurologic or dermatologic case reports.

06

Regulatory & development status

No FDA-approved Melanotan II drug product; FDA identifies significant safety concerns.

Supplied strictly for in-vitro and ex-vivo laboratory research. Not for human or veterinary administration, diagnostic, or therapeutic use. Import and regulatory compliance remain the responsibility of the receiving researcher.

07

Lot documentation

Every Cendrix lot ships with an HPLC purity chromatogram, mass-spectrometry identity confirmation, appearance and reconstitution observations, and endotoxin testing where applicable. Lot certificates are retrievable from the Quality page using the lot number printed on the vial.

08

Curated references

External searches link to PubMed, ClinicalTrials.gov, Google Scholar, and FDA records. Cendrix does not endorse interpretations published in third-party sources.

Editorial provenance

Last scientific review
June 2026
Literature search through
June 2026
Regulatory review status
Pending counsel approval

Persistent disclaimer

For laboratory research use only. Not for human or veterinary use, diagnosis, treatment, prevention, or personal experimentation. This content summarizes published research and is not medical advice.